Impacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placenta.

ABSTRACT: The placenta guides fetal growth and development. Bisphenol A (BPA) and phthalates are widespread environmental contaminants and endocrine disruptors, and the placental epigenetic response to these chemicals is an area of growing research interest. Therefore, our objective was to summarize research linking BPA or phthalate exposure to placental outcomes in human pregnancies, with a particular focus on epigenetic endpoints. In PubMed, studies were selected for review (without limiting start date and ending on 1 May 2018) if they reported any direct effects of BPA or phthalates on the placenta in humans. Collectively, available studies suggest that BPA and phthalate exposures are associated with changes to placental micro-RNA expression, DNA methylation, and genomic imprinting. Furthermore,

SUBMITTER: Strakovsky RS 

PROVIDER: S-EPMC6128378 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature