NeuroArray, A Custom CGH Microarray to Decipher Copy Number Variants in Alzheimer's Disease.

ABSTRACT:

Background

Copy Number Variants (CNVs) represent a prevailing type of structural variation (deletions or duplications) in the human genome. In the last few years, several studies have demonstrated that CNVs represent significant mutations in Alzheimer's Disease (AD) hereditability. Currently, innovative high-throughput platforms and bioinformatics algorithms are spreading to screening CNVs involved in different neurological diseases. In particular, the use of custom arrays, based on libraries of probes that can detect significant genomic regions, have greatly improved the resolution of targeted regions and the identification of chromosomal aberrations.

Objective

In this work, we report the use of NeuroArray, a custom CGH microarray useful to screening and further investigate

SUBMITTER: Cuccaro D 

PROVIDER: S-EPMC6128388 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature