Models for potential dendritic nitric oxide donors: crystal structures of two 2-nitroanilino precursors and nitric oxide-release behavior of the nitrosated derivatives.

ABSTRACT: Two molecular precursors to dendrimeric materials that could serve as slow and sustained NO-releasing therapeutic agents have been synthesized and characterized. N¹,N⁴-Bis(2-nitrophenyl)butane-1,4-diamine, C₁₆H₁₈N₄O₄, (I), crystallizes in a lattice with equal populations of two molecules of different conformations, both of which possess inversion symmetry through the central C-C bond. One molecule has exclusively anti conformations along the butyl chain, while the other has a gauche conformation of the substituents on the first C-C bond. N²,N²-Bis[2-(2-nitroanilino)ethyl]-N¹-(2-nitrophenyl)ethane-1,2-diamine, C₂₄H₂₇N₇O₆, (II), crystallizes with one

SUBMITTER: Badour AR 

PROVIDER: S-EPMC6128391 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature