Classes of depression symptom trajectories in patients with major depression receiving a collaborative care intervention.

ABSTRACT:

Purpose

Collaborative care is effective in improving symptoms of patients with depression. The aims of this study were to characterize symptom trajectories in patients with major depression during one year of collaborative care and to explore associations between baseline characteristics and symptom trajectories.

Methods

We conducted a cluster-randomized controlled trial in primary care. The collaborative care intervention comprised case management and behavioral activation. We used the Patient Health Questionnaire-9 (PHQ-9) to assess symptom severity as the primary outcome. Statistical analyses comprised latent growth mixture modeling and a hierarchical binary logistic regression model.

Results

We included 74 practices and 626 patients (310 intervention and 316 contr

SUBMITTER: Petersen JJ 

PROVIDER: S-EPMC6128457 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature