Combining in vivo and in vitro biomechanical data reveals key roles of perivascular tethering in central artery function.

ABSTRACT: Considerable insight into effectors of cardiovascular function can be gleaned from controlled studies on mice, especially given the diverse models that are available. Toward this end, however, there is a need for consistent and complementary methods of in vivo and in vitro data analysis, synthesis, and interpretation. The overall objective of this study is twofold. First, we present new semi-automated methods to quantify in vivo measurements of vascular function in anesthetized mice as well as new approaches to synthesize these data with those from in vitro biaxial mechanical characterizations. Second, we contrast regional differences in biomechanical behaviors along the central vasculature by combining biaxial strains measured in vivo with data on the unloaded geometry and biaxial materia

SUBMITTER: Ferruzzi J 

PROVIDER: S-EPMC6128471 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature