Routinely measured hematological parameters and prediction of recurrent vascular events in patients with clinically manifest vascular disease.

ABSTRACT:

Background and aims

The predictive value of traditional risk factors for vascular events in patients with manifest vascular disease is limited, underscoring the need for novel biomarkers to improve risk stratification. Since hematological parameters are routinely assessed in clinical practice, they are readily available candidates.

Methods

We used data from 3,922 vascular patients, who participated in the Second Manifestations of ARTerial Disease (SMART) study. We first investigated associations between recurrent vascular events and 22 hematological parameters, obtained from the Utrecht Patient Oriented Database (UPOD), and then assessed whether parameters associated with outcome improved risk prediction.

Results

After adjustment for all SMART risk score (SRS) variabl

SUBMITTER: Kofink D 

PROVIDER: S-EPMC6128486 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature