Effectiveness of Low Doses of Hyaluronidase to Remove Hyaluronic Acid Filler Nodules: A Randomized Clinical Trial.

ABSTRACT:

Importance

Although hyaluronidase is known to remove hyaluronic acid fillers, use of low doses has not been well studied.

Objective

To assess the effectiveness and dose-related effect of small quantities of hyaluronidase to treat hyaluronic acid filler nodules.

Design, setting, and participants

Split-arm, parallel-group, randomized clinical trial at an urban academic center. Participants were 9 healthy women. Recruitment and follow-up occurred from February 2013 to March 2014; data analysis occurred from February to July 2016.

Interventions

Each participant received aliquots (buttons) of either of 2 types of hyaluronic acid fillers into bilateral upper inner arms, respectively. At 1, 2, and 3 weeks each button was treated with a constant volume (0.1 mL) of vari

SUBMITTER: Alam M 

PROVIDER: S-EPMC6128506 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature