CAMP, Ca²⁺, pH_i, and NO Regulate H-like Cation Channels That Underlie Feeding and Locomotion in the Predatory Sea Slug Pleurobranchaea californica.

ABSTRACT: A systems approach to regulation of neuronal excitation in the mollusc Pleurobranchaea has described novel interactions of cyclic AMP-gated cation current (I_Na,cAMP), Ca²⁺, pH_i, and NO. I_Na,cAMP appears in many neurons of feeding and locomotor neuronal networks. It is likely one of the family of hyperpolarization-activated, cyclic-nucleotide-gated currents (h-current) of vertebrate and invertebrate pacemaker networks. There are two isoforms. Ca²⁺ regulates both voltage dependence and depolarization-sensitive inactivation in both isoforms. The Type 1 I_Na,cAMP of the feeding network is enhanced by intracellular acidification. A direct dependence of I_Na,cAMP on cAMP allows the current to be used as a reporter on cAMP

SUBMITTER: Green DJ 

PROVIDER: S-EPMC6128535 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature