Adipose-derived stem cell-mediated paclitaxel delivery inhibits breast cancer growth.

ABSTRACT: Breast cancer represents the main malignancy in women and autologous fat grafting is a diffuse procedure in the management of post-surgical breast defects causing patients' psychosocial problems, with high costs for the public health. Recently, beneficial effects of fat grafting during post-surgical breast reconstruction have been amplified from the enrichment with human adipose-derived stem cells (ASCs) present in the stromal vascular fraction (SVF) of adult adipose tissue isolated during intraoperatory procedures. The major concern about the ASC enrichment during post-surgery breast reconstruction depends on their potential ability to release growth factors and hormones that can promote proliferation of residual or quiescent cancer cells, with the risk of de novo cancer development or re

SUBMITTER: Scioli MG 

PROVIDER: S-EPMC6128546 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature