Spinal cord hypometabolism associated with infection by human T-cell lymphotropic virus type 1(HTLV-1).

ABSTRACT:

Background

HTLV-1 infection is endemic in Brazil. About 1 to 2% of the Brazilian population is estimated to be infected, but most infected HTLV-1 individuals do not know about their own infection, which favors the continuity of sexual and vertical virus transmission. In addition, HTLV-1 associated central nervous system diseases and their pathophysiologic mechanisms are not fully understood. This study aimed to evaluate the correlation of spinal cord metabolism, viral and inflammatory profiles with features of neurological presentation in HTLV-1 infected individuals.

Methodology

This is a cross-sectional study of a cohort including 48 HTLV-1 infected individuals clinically classified as asymptomatic-AG (N = 21), symptomatic-SG (N = 11) and HAM/TSP-HG (N = 16) and a nested ca

SUBMITTER: Romanelli LCF 

PROVIDER: S-EPMC6128630 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature