Upregulation of Suppressor of Cytokine Signaling 3 in Microglia by Cinnamic Acid.

ABSTRACT:

Background

Neuroinflammation plays an important role in the pathogenesis of various neurodegenerative diseases including Alzheimer's disease (AD). Suppressor of cytokine signaling 3 (SOCS3) is an anti-inflammatory molecule that suppresses cytokine signaling and inflammatory gene expression in different cells including microglia.

Objective

The pathways through which SOCS3 could be upregulated are poorly described. Cinnamic acid is a metabolite of cinnamon, a natural compound that is being widely used all over the world as a spice or flavoring agent. Here, we examined if cinnamic acid could upregulate SOCS3 in microglia.

Method

Microglia and astroglia isolated from mouse brain as well as BV-2 microglial cells were treated with cinnamic acid followed by monitoring the le

SUBMITTER: Chakrabarti S 

PROVIDER: S-EPMC6128770 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature