A circadian rhythm-related MTNR1B genetic variant modulates the effect of weight-loss diets on changes in adiposity and body composition: the POUNDS Lost trial.

ABSTRACT:

Purpose

A common variant of the melatonin receptor 1B (MTNR1B) gene has been related to increased signaling of melatonin, a hormone previously associated with body fatness mainly through effects on energy metabolism. We examined whether the MTNR1B variant affects changes of body fatness and composition in response to a dietary weight loss intervention.

Methods

The MTNR1B rs10830963 variant was genotyped for 722 overweight and obese individuals, who were randomly assigned to one of four diets varying in macronutrient composition. Anthropometric and body composition measurements (DXA scan) were collected at baseline and at 6 and 24 months of follow-up.

Results

Statistically significant interactions were observed between the MTNR1B genotype and low-/high-fat diet on chan

SUBMITTER: Goni L 

PROVIDER: S-EPMC6128782 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature