Neuronal network maturation differently affects secretory vesicles and mitochondria transport in axons.

ABSTRACT: Studying intracellular dynamics in neurons is crucial to better understand how brain circuits communicate and adapt to environmental changes. In neurons, axonal secretory vesicles underlie various functions from growth during development to plasticity in the mature brain. Similarly, transport of mitochondria, the power plant of the cell, regulates both axonal development and synaptic homeostasis. However, because of their submicrometric size and rapid velocities, studying the kinetics of these organelles in projecting axons in vivo is technically challenging. In parallel, primary neuronal cultures are adapted to study axonal transport but they lack the physiological organization of neuronal networks, which in turn may bias observations. We previously developed a microfluidic platform to re

SUBMITTER: Moutaux E 

PROVIDER: S-EPMC6128875 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature