Fasting and time of day independently modulate circadian rhythm relevant gene expression in adipose and skin tissue.

ABSTRACT:

Background

Intermittent fasting and time-restricted diets are associated with lower risk biomarkers for cardio-metabolic disease. The shared mechanisms underpinning the similar physiological response to these events is not established, but circadian rhythm could be involved. Here we investigated the transcriptional response to fasting in a large cross-sectional study of adipose and skin tissue from healthy volunteers (N = 625) controlling for confounders of circadian rhythm: time of day and season.

Results

We identified 367 genes in adipose and 79 in skin whose expression levels were associated (FDR < 5%) with hours of fasting conditionally independent of time of day and season, with 19 genes common to both tissues. Among these genes, we replicated 38 in human, 157 in non-hu

SUBMITTER: Couto Alves A 

PROVIDER: S-EPMC6129005 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature