Clinical Correlations of Transcriptional Profile in Patients Infected With Avian Influenza H7N9 Virus.

ABSTRACT:

Background

Avian influenza A (H7N9) viruses emerged in China in 2013 and caused zoonotic disease associated with a case-fatality ratio of over 30%. Transcriptional profiles in peripheral blood reflect host responses and can help to elucidate disease pathogenesis.

Methods

We correlated serial blood transcriptomic profiles of patients with avian influenza A (H7N9) virus infection and determined the biological significances from the analysis.

Results

We found that specific gene expression profiles in the blood were strongly correlated with the Pao 2/Fio 2 ratio and viral load in the lower respiratory tract. Cell cycle and leukocyte-related immunity were activated at the acute stage of the infection while T-cell functions and various metabolic processes were associated wi

SUBMITTER: Guan W 

PROVIDER: S-EPMC6129114 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature