β Cell dysfunction exists more than 5 years before type 1 diabetes diagnosis.

ABSTRACT:

Background

The duration and patterns of β cell dysfunction during type 1 diabetes (T1D) development have not been fully defined.

Methods

Metabolic measures derived from oral glucose tolerance tests (OGTTs) were compared between autoantibody-positive (aAb+) individuals followed in the TrialNet Pathway to Prevention study who developed diabetes after 5 or more years or less than 5 years of longitudinal follow-up (Progressors≥5, n = 75; Progressors<5, n = 474) and 144 aAb-negative (aAb-) relatives.

Results

Mean age at study entry was 15.0 ± 12.6 years for Progressors≥5; 12.0 ± 9.1 for Progressors<5; and 16.3 ± 10.4 for aAb- relatives. At baseline, Progressors≥5 already exhibited significantly lower fasting C-peptide (P < 0.01), C-peptide AUC (P < 0.001), and early C-pept

SUBMITTER: Evans-Molina C 

PROVIDER: S-EPMC6129118 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature