Survival in males with glioma and gastric adenocarcinoma correlates with mutant p53 residual transcriptional activity.

ABSTRACT:

Background

There is currently no clinical distinction between different TP53 mutations, despite increasing evidence that not all mutations have equally deleterious effects on the activity of the encoded tumor suppressor protein p53. The objective of this study was to determine whether these biological differences have clinical significance.

Methods

This retrospective cohort analysis included 2,074 patients with sporadic TP53 mutations (403 unique mutations) and 1,049 germline TP53 mutation carriers (188 unique mutations). Survival was projected by stratifying patients according to their p53 mutant-specific residual transcriptional activity scores.

Results

Pan-cancer survival analyses revealed a strong association between increased mutant p53 residual activity and impr

SUBMITTER: Fischer NW 

PROVIDER: S-EPMC6129128 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature