Circulating mitochondria in deceased organ donors are associated with immune activation and early allograft dysfunction.

ABSTRACT: Brain death that occurs in the setting of deceased organ donation for transplantation is associated with systemic inflammation of unknown origin. It has recently been recognized that mitochondria-derived damage-associated molecular patterns (mtDAMPs) released into the circulation in the setting of trauma and tissue injury are associated with a systemic inflammatory response. We examined the blood of deceased organ donors and found elevated levels of inflammatory cytokines and chemokines that correlated with levels of mtDAMPs. We also found that donor neutrophils are activated and that donor plasma contains a neutrophil-activating factor that is blocked by cyclosporin H, a formyl peptide receptor-1 antagonist. Examination of donor plasma by electron microscopy and flow cytometry revealed th

SUBMITTER: Pollara J 

PROVIDER: S-EPMC6129133 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature