Coherent Timescales and Mechanical Structure of Multicellular Aggregates.

ABSTRACT: Multicellular aggregates are an excellent model system to explore the role of tissue biomechanics in specifying multicellular reorganization during embryonic developments and malignant invasion. Tissue-like spheroids, when subjected to a compressive force, are known to exhibit liquid-like behaviors at long timescales (hours), largely because of cell rearrangements that serve to effectively dissipate the applied stress. At short timescales (seconds to minutes), before cell rearrangement, the mechanical behavior is strikingly different. The current work uses shape relaxation to investigate the structural characteristics of aggregates and discovers two coherent timescales: one on the order of seconds, the other tens of seconds. These timescales are universal, conserved across a variety of tes

SUBMITTER: Yu M 

PROVIDER: S-EPMC6129187 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature