Effect of Loading History on Airway Smooth Muscle Cell-Matrix Adhesions.

ABSTRACT: Integrin-mediated adhesions between airway smooth muscle (ASM) cells and the extracellular matrix (ECM) regulate how contractile forces generated within the cell are transmitted to its external environment. Environmental cues are known to influence the formation, size, and survival of cell-matrix adhesions, but it is not yet known how they are affected by dynamic fluctuations associated with tidal breathing in the intact airway. Here, we develop two closely related theoretical models to study adhesion dynamics in response to oscillatory loading of the ECM, representing the dynamic environment of ASM cells in vivo. Using a discrete stochastic-elastic model, we simulate individual integrin binding and rupture events and observe two stable regimes in which either bond formation or bond ruptur

SUBMITTER: Irons L 

PROVIDER: S-EPMC6129191 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature