Recurrence of nephrotic syndrome following kidney transplantation is associated with initial native kidney biopsy findings.

ABSTRACT:

Background and objectives

Steroid-resistant nephrotic syndrome (SRNS) due to focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) is a leading cause of end-stage kidney disease in children. Recurrence of primary disease following transplantation is a major cause of allograft loss. The clinical determinants of disease recurrence are not completely known. Our objectives were to determine risk factors for recurrence of FSGS/MCD following kidney transplantation and factors that predict response to immunosuppression following recurrence.

Methods

Multicenter study of pediatric patients with kidney transplants performed for ESKD due to SRNS between 1/2006 and 12/2015. Demographics, clinical course, and biopsy data were collected. Patients with primary-SRNS (PS

SUBMITTER: Pelletier JH 

PROVIDER: S-EPMC6129203 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature