Cytotoxic CD8⁺ T cells recognize and kill Plasmodium vivax-infected reticulocytes.

ABSTRACT: Plasmodium vivax causes approximately 100 million clinical malaria cases yearly^1,2. The basis of protective immunity is poorly understood and thought to be mediated by antibodies^3,4. Cytotoxic CD8⁺ T cells protect against other intracellular parasites by detecting parasite peptides presented by human leukocyte antigen class I on host cells. Cytotoxic CD8⁺ T cells kill parasite-infected mammalian cells and intracellular parasites by releasing their cytotoxic granules^5,6. Perforin delivers the antimicrobial peptide granulysin and death-inducing granzymes into the host cell, and granulysin then delivers granzymes into the parasite. Cytotoxic CD8⁺ T cells were thought to have no role against Plasmodium spp. blood stages because

SUBMITTER: Junqueira C 

PROVIDER: S-EPMC6129205 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature