Prioritising candidate genes causing QTL using hierarchical orthologous groups.

ABSTRACT:

Motivation

A key goal in plant biotechnology applications is the identification of genes associated to particular phenotypic traits (for example: yield, fruit size, root length). Quantitative Trait Loci (QTL) studies identify genomic regions associated with a trait of interest. However, to infer potential causal genes in these regions, each of which can contain hundreds of genes, these data are usually intersected with prior functional knowledge of the genes. This process is however laborious, particularly if the experiment is performed in a non-model species, and the statistical significance of the inferred candidates is typically unknown.

Results

This paper introduces QTLSearch, a method and software tool to search for candidate causal genes in QTL studies by combining Gen

SUBMITTER: Warwick Vesztrocy A 

PROVIDER: S-EPMC6129274 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature