Understanding the evolution of functional redundancy in metabolic networks.

ABSTRACT:

Motivation

Metabolic networks have evolved to reduce the disruption of key metabolic pathways by the establishment of redundant genes/reactions. Synthetic lethals in metabolic networks provide a window to study these functional redundancies. While synthetic lethals have been previously studied in different organisms, there has been no study on how the synthetic lethals are shaped during adaptation/evolution.

Results

To understand the adaptive functional redundancies that exist in metabolic networks, we here explore a vast space of 'random' metabolic networks evolved on a glucose environment. We examine essential and synthetic lethal reactions in these random metabolic networks, evaluating over 39 billion phenotypes using an efficient algorithm previously developed in our lab

SUBMITTER: Sambamoorthy G 

PROVIDER: S-EPMC6129275 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature