GGRaSP: a R-package for selecting representative genomes using Gaussian mixture models.

ABSTRACT: Motivation:The vast number of available sequenced bacterial genomes occasionally exceeds the facilities of comparative genomic methods or is dominated by a single outbreak strain, and thus a diverse and representative subset is required. Generation of the reduced subset currently requires a priori supervised clustering and sequence-only selection of medoid genomic sequences, independent of any additional genome metrics or strain attributes. Results:The Gaussian Genome Representative Selector with Prioritization (GGRaSP) R-package described below generates a reduced subset of genomes that prioritizes maintaining genomes of interest to the user as well as minimizing the loss of genetic variation. The package also allows for unsupervised clustering by modeling the genomic relationships using

SUBMITTER: Clarke TH 

PROVIDER: S-EPMC6129299 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature