PhenotypeSimulator: A comprehensive framework for simulating multi-trait, multi-locus genotype to phenotype relationships.

ABSTRACT:

Motivation

Simulation is a critical part of method development and assessment. With the increasing sophistication of multi-trait and multi-locus genetic analysis techniques, it is important that the community has flexible simulation tools to challenge and explore the properties of these methods.

Results

We have developed PhenotypeSimulator, a comprehensive phenotype simulation scheme that can model multiple traits with multiple underlying genetic loci as well as complex covariate and observational noise structure. This package has been designed to work with many common genetic tools both for input and output. We describe the underlying components of this simulation tool and illustrate its use on an example dataset.

Availability and implementation

PhenotypeSimulator is

SUBMITTER: Meyer HV 

PROVIDER: S-EPMC6129313 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature