Sustained stimulation of β₂- and β₃-adrenergic receptors leads to persistent functional pain and neuroinflammation.

ABSTRACT: Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Consistent with clinical syndromes, our lab has shown that sustained 14-day delivery of the COMT inhibitor OR486 in rodents results in pain at multiple body sites and pain-related volitional behaviors. The onset of COMT-dependent functional pain is mediated by peripheral β₂- and β₃-adrenergic receptors (β₂- and β₃ARs) through the release of the pro-inflammatory cytokines tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), and interleukin-6 (IL-6). Here, we first sought to investigate the role of β₂- and

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6129429 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature