High-Sensitivity Troponin I and Coronary Computed Tomography in Symptomatic Outpatients With Suspected CAD: Insights From the PROMISE Trial.

ABSTRACT:

Objectives

The goal of this study was to examine associations between concentrations of high-sensitivity troponin I (hsTnI) (measured by using a single-molecule counting method) and obstructive coronary artery disease (CAD) in 1,844 stable, symptomatic outpatients with suspected CAD randomized to undergo coronary computed tomography angiography (CTA) in the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) trial.

Background

Elevated concentrations of hsTnI are associated with CAD in patients with myocardial infarction. The meaning of hsTnI concentrations in stable symptomatic outpatients is not well understood.

Methods

Clinical characteristics and CTA results (including coronary artery calcium [CAC] scores) were expressed across hsTnI quarti

SUBMITTER: Januzzi JL 

PROVIDER: S-EPMC6129434 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature