Inefficient N2-Like Neutrophils Are Promoted by Androgens During Infection.

ABSTRACT: Neutrophils are major effectors of acute inflammation against infection and tissue damage, with ability to adapt their phenotype according to the microenvironment. Although sex hormones regulate adaptive immune cells, which explains sex differences in immunity and infection, little information is available about the effects of androgens on neutrophils. We therefore aimed to examine neutrophil recruitment and plasticity in androgen-dependent and -independent sites under androgen manipulation. By using a bacterial model of prostate inflammation, we showed that neutrophil recruitment was higher in testosterone-treated rats, with neutrophil accumulation being positively correlated to serum levels of testosterone and associated to stronger inflammatory signs and tissue damage. Testosterone also

SUBMITTER: Scalerandi MV 

PROVIDER: S-EPMC6129603 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature