Encoding of danger by parabrachial CGRP neurons.

ABSTRACT: Animals must respond to various threats to survive. Neurons that express calcitonin gene-related peptide in the parabrachial nucleus (CGRP^PBN neurons) relay sensory signals that contribute to satiation and pain-induced fear behaviour, but it is unclear how they encode these distinct processes. Here, by recording calcium transients in vivo from individual neurons in mice, we show that most CGRP^PBN neurons are activated by noxious cutaneous (shock, heat, itch) and visceral stimuli (lipopolysaccharide). The same neurons are inhibited during feeding, but become activated during satiation, consistent with evidence that CGRP^PBN neurons prevent overeating. CGRP^PBN neurons are also activated during consumption of novel foods or by an auditory cue that ha

SUBMITTER: Campos CA 

PROVIDER: S-EPMC6129987 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature