Ontology highlight
ABSTRACT:
SUBMITTER: Barcena C
PROVIDER: S-EPMC6130051 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Cell reports 20180801 9
Dietary intervention constitutes a feasible approach for modulating metabolism and improving the health span and lifespan. Methionine restriction (MR) delays the appearance of age-related diseases and increases longevity in normal mice. However, the effect of MR on premature aging remains to be elucidated. Here, we describe that MR extends lifespan in two different mouse models of Hutchinson-Gilford progeria syndrome (HGPS) by reversing the transcriptome alterations in inflammation and DNA-damag ...[more]