Nucleus Basalis of Meynert Stimulation for Dementia: Theoretical and Technical Considerations.

ABSTRACT: Deep brain stimulation (DBS) of nucleus basalis of Meynert (NBM) is currently being evaluated as a potential therapy to improve memory and overall cognitive function in dementia. Although, the animal literature has demonstrated robust improvement in cognitive functions, phase 1 trial results in humans have not been as clear-cut. We hypothesize that this may reflect differences in electrode location within the NBM, type and timing of stimulation, and the lack of a biomarker for determining the stimulation's effectiveness in real time. In this article, we propose a methodology to address these issues in an effort to effectively interface with this powerful cognitive nucleus for the treatment of dementia. Specifically, we propose the use of diffusion tensor imaging to identify the nucleus and

SUBMITTER: Kumbhare D 

PROVIDER: S-EPMC6130053 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature