Design and Fabrication of a Hierarchically Structured Scaffold for Tendon-to-Bone Repair.

ABSTRACT: A hierarchically structured scaffold is designed and fabricated for facilitating tendon-to-bone repair. The scaffold is composed of three regions with distinct functions: (i) an array of channels to guide the in-growth of cells and aligned deposition of collagen fibers, as well as integration of the scaffold with the tendon side, (ii) a region with a gradient in mineral composition to facilitate stress transfer between tendon and bone, and (iii) a mineralized inverse opal region to promote the integration of the scaffold with the underlying bone. Cell culture experiments confirm that adipose-derived stromal cells are able to infiltrate and proliferate through the entire thickness of the scaffold without compromised cell viability. The seeded stem cells exhibit directed differentiation into

SUBMITTER: Zhu C 

PROVIDER: S-EPMC6130203 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature