Systemic Candidiasis and TLR2 Agonist Exposure Impact the Antifungal Response of Hematopoietic Stem and Progenitor Cells.

ABSTRACT: We have previously demonstrated that Candida albicans induces differentiation of hematopoietic stem and progenitor cells (HSPCs) toward the myeloid lineage both in vitro and in vivo in a TLR2- and Dectin-1-dependent manner, giving rise to functional macrophages. In this work, we used an ex vivo model to investigate the functional consequences for macrophages derived from HSPCs in vivo-exposed to Pam₃CSK₄ (a TLR2 agonist) or C. albicans infection. Short in vivo treatment of mice with Pam₃CSK₄ results in a tolerized phenotype of ex vivo HSPC-derived macrophages, whereas an extended Pam₃CSK₄ treatment confers a trained phenotype. Early during candidiasis, HSPCs give rise t

SUBMITTER: Martinez A 

PROVIDER: S-EPMC6130230 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature