Recurrent tuberculosis among HIV-coinfected patients: a case series from KwaZulu-Natal.

ABSTRACT:

Background

Recurrent tuberculosis (TB) following TB treatment completion in HIV-infected individuals remains a major public health burden. We assessed the role of various risk factors in mediating the development of recurrent TB and subsequent resistance to antiretroviral therapy and anti-TB drugs.

Patients and methods

We analyzed secondary demographic, clinical, and laboratory data from medical records of five HIV-infected TB patients enrolled between 2009 and 2014 in a prospective observational study investigating TB recurrence. Paired clinical isolates of Myco-bacterium tuberculosis were typed by IS6110 restriction fragment length polymorphism analysis to determine the mechanism of TB recurrence. Plasma samples were genotyped to determine acquisition of HIV

SUBMITTER: Naidoo K 

PROVIDER: S-EPMC6130302 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature