Material microenvironmental properties couple to induce distinct transcriptional programs in mammalian stem cells.

ABSTRACT: Variations in a multitude of material microenvironmental properties have been observed across tissues in vivo, and these have profound effects on cell phenotype. Phenomenological experiments have suggested that certain of these features of the physical microenvironment, such as stiffness, could sensitize cells to other features; meanwhile, mechanistic studies have detailed a number of biophysical mechanisms for this sensing. However, the broad molecular consequences of these potentially complex and nonlinear interactions bridging from biophysical sensing to phenotype have not been systematically characterized, limiting the overall understanding and rational deployment of these biophysical cues. Here, we explore these interactions by employing a 3D cell culture system that allows for the in

SUBMITTER: Darnell M 

PROVIDER: S-EPMC6130338 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature