Ontology highlight
ABSTRACT:
SUBMITTER: Sanz-Murillo M
PROVIDER: S-EPMC6130403 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Sanz-Murillo Marta M Xu Jun J Belogurov Georgiy A GA Calvo Olga O Gil-Carton David D Moreno-Morcillo María M Wang Dong D Fernández-Tornero Carlos C
Proceedings of the National Academy of Sciences of the United States of America 20180820 36
RNA polymerase I (Pol I) transcribes ribosomal DNA (rDNA) to produce the ribosomal RNA (rRNA) precursor, which accounts for up to 60% of the total transcriptional activity in growing cells. Pol I monitors rDNA integrity and influences cell survival, but little is known about how this enzyme processes UV-induced lesions. We report the electron cryomicroscopy structure of Pol I in an elongation complex containing a cyclobutane pyrimidine dimer (CPD) at a resolution of 3.6 Å. The structure shows th ...[more]