Involvement of the Cingulate Cortex in Anosognosia: A Multimodal Neuroimaging Study in Alzheimer's Disease Patients.

ABSTRACT:

Background

Anosognosia is a frequent symptom of Alzheimer's disease (AD), but its neural substrates remain in question.

Objective

In this study, we combined neuroimaging with a neuropsychological evaluation to assess neural substrates of anosognosia.

Methods

We prospectively recruited 30 patients with probable early-stage AD and matched healthy controls. Participants underwent MRI, FDG-PET, and a neuropsychological evaluation that includes an assessment of anosognosia. In the AD group, correlations between the anosognosia score, neuroimaging modalities, and neuropsychological performance were performed.

Results

Atrophy and hypometabolism were correlated with the anosognosia score in the left dorsal anterior cingulate cortex. The anosognosia score was also corre

SUBMITTER: Guerrier L 

PROVIDER: S-EPMC6130407 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature