Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea.

ABSTRACT:

Context

There is an unmet need to discover new treatments for Alzheimer's disease. This study determined the anti-acetylcholinesterase (AChE) activity, DPPH free radical scavenging and antioxidant properties of Carpolobia lutea G. Don (Polygalaceae).

Objective

The objective of this study is to quantify C. lutea anti-AChE, DPPH free radical scavenging, and antioxidant activities and cell cytotoxicity.

Materials and methods

Plant stem, leaves and roots were subjected to sequential solvent extractions, and screened for anti-AChE activity across a concentration range of 0.02-200 μg/mL. Plant DPPH radical scavenging activity, reducing power, and total phenolic and flavonoid contents were determined, and cytotoxicity evaluated using human hepatocytes.

Results

Carpolo

SUBMITTER: Nwidu LL 

PROVIDER: S-EPMC6130458 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature