Inhibition of key enzymes linked to type 2 diabetes by compounds isolated from Aframomum melegueta fruit.

ABSTRACT:

Context

The use of Aframomum melegueta K. Schum. (Zingiberaceae) fruit for treatment of diabetes has recently been established in Nigeria. However, compounds responsible for the antidiabetic action have not been identified.

Objective

The present study carried out the bioassay-guided isolation of possible bioactive compounds responsible for the antidiabetic action of A. melegueta fruit.

Materials and methods

The A. melegueta fruit was sequentially extracted using ethyl acetate (EtOAc), ethanol and water, and the most active extract (EtOAc) was subjected to column chromatography on a silica gel column using solvent gradient systems of hexane (HEX):EtOAc and EtOAc:MeOH and the isolation of compounds was guided by α-glycosidase and α-amylase inhibitory activities at vario

SUBMITTER: Mohammed A 

PROVIDER: S-EPMC6130490 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature