Antibacterial activities of chemical constituents from the aerial parts of Hedyotis pilulifera.

ABSTRACT:

Context

Hedyotis pilulifera (Pit.) T.N. Ninh (Rubiaceae) has been used in Vietnamese ethnomedicine; the methanol extract exhibited antibacterial activity in our preliminary screening.

Objectives

In this study, compounds from H. pilulifera were isolated and their antibacterial activity in vitro was evaluated.

Materials and methods

The aerial parts of H. pilulifera (1.4 kg) were extracted with MeOH, suspended in water and ethyl acetate extract was chromatographed on a silica gel column. The structures of isolated compounds were elucidated by the combination analyses of spectroscopy including 1D-, 2D-NMR, HRMS and in comparison with the reported NMR data in the literature. All isolated compounds were evaluated for inhibitory effect using the microdilution method toward S

SUBMITTER: Nguyen HT 

PROVIDER: S-EPMC6130504 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature