Functional and structural connectome properties in the 5XFAD transgenic mouse model of Alzheimer's disease.

ABSTRACT: Neurodegeneration in Alzheimer's disease (AD) is associated with amyloid-beta peptide accumulation into insoluble amyloid plaques. The five-familial AD (5XFAD) transgenic mouse model exhibits accelerated amyloid-beta deposition, neuronal dysfunction, and cognitive impairment. We aimed to determine whether connectome properties of these mice parallel those observed in patients with AD. We obtained diffusion tensor imaging and resting-state functional magnetic resonance imaging data for four transgenic and four nontransgenic male mice. We constructed both structural and functional connectomes and measured their topological properties by applying graph theoretical analysis. We compared connectome properties between groups using both binarized and weighted networks. Transgenic mice showed high

SUBMITTER: Kesler SR 

PROVIDER: S-EPMC6130552 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature