Acute and sub-chronic toxicity of Cajanus cajan leaf extracts.

ABSTRACT:

Context

The leaves of Cajanus cajan (L.) Millsp. (Fabaceae) have diverse bioactivities, but little safety data are reported.

Objective

This study examines the toxicological profiles of C. cajan leaf extracts.

Materials and methods

The leaves were extracted by water or 90% ethanol to obtain water or ethanol extract (WEC or EEC). EEC was suspended in water and successively fractionated into dichloroform and n-butanol extracts (DEC and BEC). Marker compounds of the extracts were monitored by high-performance liquid chromatography (HPLC). Kunming mice were administered with a single maximum acceptable oral dose (15.0 g/kg for WEC, EEC and BEC and 11.3 g/kg for DEC) to determine death rate or maximal tolerated doses (MTDs). In sub-chronic toxicity investigation, Sprague-Da

SUBMITTER: Tang R 

PROVIDER: S-EPMC6130582 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature