Phytochemical investigations and antiproliferative secondary metabolites from Thymus alternans growing in Slovakia.

ABSTRACT:

Context

Thymus alternans Klokov (Lamiaceae) is a neglected species of the genus Thymus (Sect. Serpyllum) endemic to Carpathian area, where it is used as a flavouring agent and for medicinal purposes.

Objective

The aim of the work was to identify antiproliferative constituents from the flowering aerial parts of this plant.

Materials and methods

Thymus alternans extracts were analyzed by HPLC-MSⁿ and subjected to extensive chromatographic separations. The isolated compounds (phenolics and triterpenes) were structurally elucidated by MS and 1D and 2D NMR experiments. Essential oil (EO) composition was determined by GC-FID and GC-MS. Six purified triterpenes and EO were assayed for in vitro antiproliferative activity against a panel of human cancer cells, namel

SUBMITTER: Dall'Acqua S 

PROVIDER: S-EPMC6130594 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature