Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts.

ABSTRACT:

Context

Clove (Eugenia caryophyllata Thunb. [Myrtaceae]) essential oil (CEO) has been shown to possess antimicrobial, antifungal, antiviral, antioxidant, anti-inflammatory and anticancer properties. However, few studies have focused on its topical use.

Objective

We investigated the biological activity of a commercially available CEO in a human skin disease model.

Materials and methods

We evaluated the effect of CEO on 17 protein biomarkers that play critical roles in inflammation and tissue remodelling in a validated human dermal fibroblast system, which was designed to model chronic inflammation and fibrosis. Four concentrations of CEO (0.011, 0.0037, 0.0012, and 0.00041%, v/v) were studied. The effect of 0.011% CEO on genome-wide gene expression was also evaluated.<

SUBMITTER: Han X 

PROVIDER: S-EPMC6130734 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature