Gestational diabetes modifies the association between PlGF in early pregnancy and preeclampsia in women with obesity.

ABSTRACT:

Objective

To identify clinical and biomarker risk factors for preeclampsia in women with obesity and to explore interactions with gestational diabetes, a condition associated with preeclampsia.

Study design

In women with obesity (body mass index ≥ 30 kg/m²) from the UK Pregnancies Better Eating and Activity Trial (UPBEAT), we examined 8 clinical factors (socio-demographic characteristics, BMI, waist circumference and clinical variables) and 7 biomarkers (HDL cholesterol, hemoglobin A1c, adiponectin, interleukin-6, high sensitivity C-reactive protein, and placental growth factor (PlGF)) in the early second trimester for association with later development of preeclampsia using logistic regression. Factors were selected based on prior association with preeclampsia. I

SUBMITTER: Vieira MC 

PROVIDER: S-EPMC6130745 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature