Chemical composition and cytotoxic properties of Clinacanthus nutans root extracts.

ABSTRACT:

Context

Clinacanthus nutans Lindau (Acanthaceae) is a medicinal plant that has been reported to have anti-inflammatory, antiviral, antimicrobial and antivenom activities. In Malaysia, it has been widely claimed to be effective in various cancer treatments but scientific evidence is lacking.

Objective

This study investigates the chemical constituents, anti-proliferative, and apoptotic properties of C. nutans root extracts.

Materials and methods

The roots were subjected to solvent extraction using methanol and ethyl acetate. The anti-proliferative effects of root extracts were tested at the concentrations of 10 to 50 μg/mL on MCF-7 and HeLa by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay for 72 h. Morphological changes were observed un

SUBMITTER: Teoh PL 

PROVIDER: S-EPMC6130766 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature