Exploring Selectivity of Multikinase Inhibitors across the Human Kinome.

ABSTRACT: Selectivity of kinase inhibitors, or the lack thereof, continues to be an intensely debated topic in drug discovery research. Especially, type I inhibitors, which represent most of the currently available kinase inhibitors, are often thought to lack selectivity because they target the largely conserved adenosine triphosphate-binding site in kinases. Herein, we present a large-scale analysis of potential selectivity among multikinase inhibitors, covering 141 human kinases and more than 10 000 qualifying compounds. By design, the analysis was focused on type I inhibitors and carried out at the level of systematically generated kinase pairs sharing inhibitors. Kinase pair category- and compound-based selectivity profiles identified in part highly selective inhibitors for many kinases. Sets of

SUBMITTER: Miljkovic F 

PROVIDER: S-EPMC6130781 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature