Self-Calibration Phenomenon for Near-Infrared Clinical Measurements: Theory, Simulation, and Experiments.

ABSTRACT: An irradiated turbid medium scatters the light in accordance to its optical properties. Near-infrared (NIR) clinical methods, which are based on spectral-dependent absorption, suffer from an inherent error due to spectral-dependent scattering. We present here a unique spatial point, that is, iso-pathlength (IPL) point, on the surface of a tissue at which the intensity of re-emitted light remains constant. This scattering-indifferent point depends solely on the medium geometry. On the basis of this natural phenomenon, we suggest a novel optical method for self-calibrated clinical measurements. We found that the IPL point exists in both cylindrical and semi-infinite tissue geometries (Supporting Information, Video file). Finally, in vivo human finger and mice measurements are used to validat

SUBMITTER: Feder I 

PROVIDER: S-EPMC6130783 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature