Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer.

ABSTRACT: The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumor evolution is poorly understood. Phenotypic drifts can be transmitted via inheritable transcriptional programs. Cell-type specific transcription is maintained through the activation of epigenetically defined regulatory regions including promoters and enhancers. Here we have annotated the epigenome of 47 primary and metastatic estrogen-receptor (ERα)-positive breast cancer clinical specimens and inferred phenotypic heterogeneity from the regulatory landscape, identifying key regulatory elements commonly shared across patients. Shared regions contain a unique set of regulatory information including the motif for transcription factor YY1. We identify YY1 as a critical determinant of ERα transcriptional acti

SUBMITTER: Patten DK 

PROVIDER: S-EPMC6130800 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature